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Evogene Announces a Significant Milestone in its Next Generation Herbicide Pipeline

Rehovot, Israel – September 5, 2018 – Evogene Ltd. (NASDAQ, TASE: EVGN), a leading biotechnology company developing novel products for life science markets, announced today a significant milestone in its next generation herbicide pipeline. Evogene’s Ag-Chemicals division demonstrated biological proof in lab assays that Evogene discovered molecule families bind to essential target proteins representing new MoA’s (Mode-of-Action). These next generation herbicide candidates have the potential to overcome the industry’s main hurdle – growing weed resistance, with improved efficacy while maintaining a high standard of safety since they have now been proven to address novel target proteins not present in humans.

Herbicides are weed killing chemicals, part of the general pesticide and crop protection market. The market size attributed to herbicides was estimated at more than $20B in 2016[1]. Herbicide protection plays an important role in global food security; for example, without herbicide protection it is estimated that approximately 20% of the global crop yield of wheat would be lost[2]. Current herbicide products are based on known targets and MoA’s introduced to market over 30 years ago, while weed resistance to these solutions is globally on the rise, creating a critical need for next generation herbicides based on new MoA’s.

Evogene’s Ag-Chemicals division herbicide pipeline has been established through the use of the Company’s broadly applicable CPB (Computational Predictive Biology) platform. The CPB platform’s discovery and optimization processes of chemical molecules take into account an array of product attributes, including different aspects of commercial viability and safety profile required according to new regulatory standards.

As reported in the past, these chemical families have already been evaluated in lab and greenhouse testing where herbicidal activity was demonstrated, and today, Evogene has announced that such chemical families were also proven to inhibit the predicted novel targets representing a new MoA. These chosen novel targets are not present in humans and therefore have a potential high safety profile.

Further steps include optimization of the chemical compound ‘families’ to improve herbicidal efficacy in greenhouse testing, towards achieving commercial efficacy, which will then be validated in field trials.

Eran Kosover, EVP and GM, Ag-Chemicals stated: “We are very excited by the important achievement announced today, as the industry has not seen a herbicide based on a new MoA for over 30 years. We are now moving forward rapidly on a development path designed to overcome one of the most pressing challenges in the market – increasing resistance to herbicides.”

Ofer Haviv, Evogene’s President and CEO stated: “While our Ag-Chemicals division was established only in 2014, we are happy by the continuous progress of this division and the milestone announced today, showing a new MoA with the binding of Evogene discovered chemicals to novel target proteins. This continuous progress was achieved with the use of our unique CPB platform. We believe that these unique capabilities are leading to the development of potent next generation herbicides with a high safety profile.”


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